The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural
products (such as the anticoagulant warfarin) that display interesting pharmacological …

Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by
damage of the myelin sheath that covers most of nerve fibers of the central and peripheral …

Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating
the sulfation states that determine the function of many physiological molecules. Sulfatase …

C α-formylglycine (FGly) is the catalytic residue in the active site of eukaryotic sulfatases. It is
posttranslationally generated from a cysteine in the endoplasmic reticulum. The genetic …

Formylglycine (fGly) is a catalytically essential residue found almost exclusively in the active
sites of type I sulfatases. Formed by post-translational oxidation of cysteine or serine side …

Multidrug-resistant (MDR) gram-negative bacteria have increased the prevalence of fatal
sepsis in modern times. Colistin is a cationic antimicrobial peptide (CAMP) antibiotic that …

The majority of lysosomal storage diseases affect the brain. Treatment of the brain with
intravenous enzyme replacement therapy is not successful, because the recombinant …

Covering: up to the end of 2017 The human body is composed of an equal number of
human and microbial cells. While the microbial community inhabiting the human …

Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties
whose highly ordered composition is central to directing specific cell signaling events. The …