Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …
to acute respiratory distress syndrome and death. Three highly pathogenic human …
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda… - Nature, 2022 - nature.com
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …
production, viral RNA and a sustained interferon (IFN) response, all of which are …
Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
S Chakraborty, JC Gonzalez, BL Sievers… - Science Translational …, 2022 - science.org
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …
mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses …
JS Buhre, T Pongracz, I Künsting, AS Lixenfeld… - Frontiers in …, 2023 - frontiersin.org
Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …
[HTML][HTML] Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study
Background Immunocompromised patients may be at higher risk of mortality if hospitalised
with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients …
with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Regulation of VWF (von Willebrand factor) in inflammatory thrombosis
XD Manz, HJ Bogaard, J Aman - Arteriosclerosis, thrombosis, and …, 2022 - Am Heart Assoc
Increasing evidence indicates that inflammation promotes thrombosis via a VWF (von
Willebrand factor)-mediated mechanism. VWF plays an essential role in maintaining the …
Willebrand factor)-mediated mechanism. VWF plays an essential role in maintaining the …