Peritoneal surface malignancies comprise a heterogeneous group of primary tumours,
including peritoneal mesothelioma, and peritoneal metastases of other tumours, including …

Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used
to study the genomics, transcriptomics, and epigenetics at a single cell level. SCS is widely …

Epithelial ovarian cancer (EOC) cells metastasize within the peritoneal cavity and directly
encounter human peritoneal mesothelial cells (HPMC) as the initial step of metastasis. The …

An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …

Highlights•Tumor tissues stiffen in disease, but cancer cells can soften.•Some cancer cell
types lose aspects of stiffness sensing.•Ras, FAK and PI3K/Akt signaling have been …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are
covalently attached. Although a small number of proteins have the capacity to be glycanated …

Ovarian adenocarcinoma is characterized by a late detection, dissemination of cancer cells
into the whole peritoneum, and the frequent acquisition of chemoresistance. If these …

Background Accumulation and infiltration of microglia/brain macrophages around and into
glioma tissue promote tumor invasion and expansion. One tumor-promoting mechanism of …