There are currently no consistent objective biochemical markers of alcohol abuse and
alcoholism. Development of reliable diagnostic biomarkers that permit accurate assessment …

Genetic and biochemical studies have established a central role for α-synuclein
accumulation in the pathogenesis of Parkinson disease. Here, two microRNAs, namely mir-7 …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
accumulation of α-Synuclein (a-Syn) into Lewy body inclusions and the loss of dopaminergic …

Genetic and environmental factors play a role in the development of alcoholism. Whole-
genome expression profiling has highlighted the importance of several genes that may …

Alcoholism and alcohol use disorders are characterized by several months to decades of
heavy and problematic drinking, interspersed with periods of abstinence and relapse to …

We have used a translational Convergent Functional Genomics (CFG) approach to discover
genes involved in alcoholism, by gene-level integration of genome-wide association study …

Background: Studies have found that genomic variation in the gene SNCA, which encodes
the protein α‐synuclein, may contribute to the variation in alcohol consumption in an inbred …

Abstract α‐Synuclein is a key player in the pathogenesis of Parkinson disease (PD).
Expression of human heme oxygenase‐1 (HO‐1) in astrocytes of GFAP. HMOX1 transgenic …

It is well established that heavy ethanol consumption interferes with the immune system and
inflammatory processes, resulting in increased risk for infectious and chronic diseases …

Alpha-synuclein (α-Syn) is a 140-amino acid (aa) protein encoded by the Synuclein alpha
SNCA gene. It is the synaptic protein associated with Parkinson's disease (PD) and is the …