The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …

Peripheral chemosensitivity is clinically assessed by measuring the ventilatory response,
changes of muscle sympathetic nerve activity, or physiological changes in heart rate or …

Arterial hypertension is the most prevalent modifiable risk factor associated with
cardiovascular morbidity and mortality. Although antihypertensive drugs are widely …

In view of the high proportion of individuals with resistance to antihypertensive medication
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …

The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic
diseases. With the expansive functions of the chemoreflex, we sought mechanisms to …

560 Hypertension September 2018 of interest in the potential contribution of sympatho-
respiratory coupling to SNA elevation in neurogenic hypertension. As summarized below …

Substantial advances have been made recently into the discovery of fundamental
mechanisms underlying the neural control of breathing and even some inroads into …

Bilateral bipolar electric carotid sinus stimulation acutely reduced muscle sympathetic nerve
activity (MSNA) and blood pressure (BP) in patients with resistant arterial hypertension but is …

The importance of chemoreflex function for cardiovascular health is increasingly recognized
in clinical practice. The physiological function of the chemoreflex is to constantly adjust …