Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …

Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn -
Clinics in Perinatology Skip to Main Content Advertisement Clinics in Perinatology Log in …

Oxygen therapy is common during the neonatal period to improve survival, but it can
increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in …

Persistent pulmonary hypertension of the newborn (PPHN) is a frequent cause for admission
to the neonatal intensive care unit and is associated with mortality and variable morbidities …

Oxidative stress can be associated with hyperoxia and hypoxia and is characterized by an
increase in reactive oxygen (ROS) and nitrogen (RNS) species generated by an underlying …

The fetal circulation uses a series of adaptive mechanisms to maximize delivery of oxygen to
the most metabolically active tissues. Blood returning from the placenta through the …

Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe
cardiovascular and neurological consequences. One of its main causes is hypoxia during …

Exposure of newborn mice to high inspired oxygen elicits a distinct phenotype of
compromised alveolar and vascular development, although lethality during long-term …