Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in
the rapid growth of cancer cells as well as the formation of metastatic lesions …

Cholesterol is essential for a variety of functions in endocrine-related cells, including
hormone and steroid production. We have reviewed the progress to date in research on the …

Bladder cancer is the fourth most common malignancy in males. It can present across the
whole continuum of severity, from mild through well-differentiated disease to extremely …

Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a
protein activated by ligands that interacts with the promoters of specific genes. It regulates …