Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …

Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …

Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …

Most mammalian genes produce multiple distinct messenger RNAs through alternative
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription,
splicing, and polyadenylation. However, the relationship between human transcript diversity …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single
gene can encode multiple distinct transcripts, has been proposed to underlie morphological …

Differentiated cells acquire unique structural and functional traits through coordinated
expression of lineage-specific genes. An extensive battery of genes encoding components …