Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

S Lykke-Andersen, TH Jensen - Nature reviews Molecular cell biology, 2015 - nature.com
Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …

Complexity of the alternative splicing landscape in plants

ASN Reddy, Y Marquez, M Kalyna, A Barta - The Plant Cell, 2013 - academic.oup.com
Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …

[HTML][HTML] Mechanism of alternative splicing and its regulation

Y Wang, J Liu, BO Huang, YM Xu… - Biomedical …, 2015 - … .spandidos-publications.com
Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …

Evolutionary dynamics of gene and isoform regulation in Mammalian tissues

J Merkin, C Russell, P Chen, CB Burge - Science, 2012 - science.org
Most mammalian genes produce multiple distinct messenger RNAs through alternative
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …

Targeting mRNA processing as an anticancer strategy

J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Tunable protein synthesis by transcript isoforms in human cells

SN Floor, JA Doudna - Elife, 2016 - elifesciences.org
Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription,
splicing, and polyadenylation. However, the relationship between human transcript diversity …

[HTML][HTML] Dynamic integration of splicing within gene regulatory pathways

U Braunschweig, S Gueroussov, AM Plocik… - Cell, 2013 - cell.com
Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

Organizing principles of mammalian nonsense-mediated mRNA decay

MWL Popp, LE Maquat - Annual review of genetics, 2013 - annualreviews.org
Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

Alternative splicing and the evolution of phenotypic novelty

SJ Bush, L Chen… - … Transactions of the …, 2017 - royalsocietypublishing.org
Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single
gene can encode multiple distinct transcripts, has been proposed to underlie morphological …

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

K Yap, ZQ Lim, P Khandelia, B Friedman… - Genes & …, 2012 - genesdev.cshlp.org
Differentiated cells acquire unique structural and functional traits through coordinated
expression of lineage-specific genes. An extensive battery of genes encoding components …