Chronic myeloid leukemia (CML) is a stem cell disorder characterized by unrestricted
proliferation of the myeloid series that occurs due to the BCR-ABL fusion oncogene as a …

Parkinson's disease is a progressive neurodegenerative disorder that predominantly affects
motor function due to the loss of dopaminergic neurons in the substantia nigra. It presents …

Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen
species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide …

Abstract Background Glutathione S‐transferases (GSTs) polymorphisms may impact on
chronic myeloid leukemia (CML) risk or heterogeneous responses to Imatinib mesylate (IM) …

Occupational exposure to benzene has been associated with leukemia, anemia,
leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may …

Background Exposure to traffic-related air pollution is associated with an increased risk of
cardiovascular and respiratory disease. Evidence suggests that inhaled pollutants …

Background Chronic myeloid leukemia (CML) is associated to the BCR-ABL1 oncogene and
can successfully be treated with tyrosine kinase inhibitors (TKIs). However, it remains still …

The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics,
including an array of environmental carcinogens, pollutants, and drugs. Genetic …

Chronic myeloid leukemia (CML), as most of cancers results from a complex interaction
between genetic or non genetic factors. Exposures to xenobiotics endogenous or …

Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental
and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual …