Females have increased pain sensitivity and are more vulnerable to chronic pain conditions.
Sleep disturbances are comorbid with chronic pain and exacerbate pain symptoms. Different …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Sleep loss heightens pain sensitivity, but the pathways underlying this association are not
known. Given that experimental sleep disruption induces increases in cellular inflammation …

Rationale Synthetic opioids like fentanyl are contributing to the rise in rates of opioid use
disorder and drug overdose deaths. Sleep dysfunction and circadian rhythm disruption may …

Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in
animals and humans, for example by increasing sensitivity to pain. However, the mechanism …

Objectives Pain as central symptom of osteoarthritis (OA) needs to be addressed as part of
successful treatment. The assessment of pain as feature of disease or outcome in clinical …

Persistent pain after groin hernia repair is a major health problem. Sleep disturbance is
associated with heightened pain sensitivity. The main objective of this study was to examine …

The opioid epidemic remains a significant healthcare problem and is attributable to over
100,000 deaths per year. Poor sleep increases sensitivity to pain, impulsivity, inattention …

Abstract Purpose of Review The purpose of this review is to provide a summary of the
utilization of sleep as a therapeutic target for chronic pain and to evaluate the recent …

Abstract Purpose of Review In this review, we provide the basis of a mechanistic model, the
sleep-reward-pain pathway, which might explain the relationship between sleep disruption …