This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

Resistance arteries and downstream arterioles in the peripheral microcirculation contribute
substantially to peripheral vascular resistance, control of blood pressure, the distribution of …

Pressure-dependent chronotropy of murine lymphatic collecting vessels relies on the
activation of the Ca2+-activated chloride channel encoded by Anoctamin 1 (Ano1) in …

High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a
rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+ …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …

Maintaining constant blood flow in the face of fluctuations in blood pressure is a critical
autoregulatory feature of cerebral arteries. An increase in pressure within the artery lumen …