The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications
Review of pro-and anti-inflammatory cytokines, and their dependence on the local
concentration of a given cytokine, the stage of disease in which it is administered, and its …
concentration of a given cytokine, the stage of disease in which it is administered, and its …
Therapeutic potential of kappa opioid agonists
TC Beck, MA Hapstack, KR Beck, TA Dix - Pharmaceuticals, 2019 - mdpi.com
Many original research articles have been published that describe findings and outline
areas for the development of kappa-opioid agonists (KOAs) as novel drugs; however, a …
areas for the development of kappa-opioid agonists (KOAs) as novel drugs; however, a …
Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
C Moussion, JP Girard - Nature, 2011 - nature.com
While patrolling the body in search of foreign antigens, naive lymphocytes continuously
circulate from the blood, through the lymph nodes, into the lymphatic vessels and back to the …
circulate from the blood, through the lymph nodes, into the lymphatic vessels and back to the …
Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes …
MAL Gabbay, MN Sato, C Finazzo… - … of pediatrics & …, 2012 - jamanetwork.com
Objective To evaluate the effect of vitamin D 3 on cytokine levels, regulatory T cells, and
residual β-cell function decline when cholecalciferol (vitamin D 3 administered …
residual β-cell function decline when cholecalciferol (vitamin D 3 administered …
Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment
Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …
CCR2 regulates the immune response by modulating the interconversion and function of effector and regulatory T cells
Chemokines and chemokine receptors establish a complex network modulating immune cell
migration and localization. These molecules were also suggested to mediate the …
migration and localization. These molecules were also suggested to mediate the …
Major depressive disorder comorbid with general anxiety disorder: Associations among neuroticism, adult stress, and the inflammatory index
X Wang, J Lin, Q Liu, X Lv, G Wang, J Wei… - Journal of psychiatric …, 2022 - Elsevier
Accumulating evidence shows that higher neuroticism and adult stress may be potential risk
factors for major depressive disorder (MDD) comorbid with generalized anxiety disorder …
factors for major depressive disorder (MDD) comorbid with generalized anxiety disorder …
Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions
The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-
binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The …
binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The …
Proinflammatory phenotype in major depressive disorder with adulthood adversity: In line with social signal transduction theory of depression
J Lin, JT Li, L Kong, Q Liu, X Lv, G Wang, J Wei… - Journal of Affective …, 2023 - Elsevier
Background The social signal transduction theory of depression proposes that life stress can
be transformed into inflammatory signals, and ultimately lead to the development of major …
be transformed into inflammatory signals, and ultimately lead to the development of major …
Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative …
Loss of immune function and increased hematopoietic disease are among the most clinically
significant consequences of aging. Hematopoietic stem cells (HSCs) from mice lacking aryl …
significant consequences of aging. Hematopoietic stem cells (HSCs) from mice lacking aryl …