Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause
of functional intestinal obstruction with an incidence of 1/5000 live births. This …

The enteric nervous system is the part of the autonomic nervous system that directly controls
the gastrointestinal tract. Derived from a multipotent, migratory cell population called the …

Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by
multiple clinical features that include pigmentary retinal dystrophy, polydactyly, obesity …

Hirschsprung disease (HSCR, aganglionic megacolon) is the main genetic cause of
functional intestinal obstruction with an incidence of 1/5000 live births. This developmental …

The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an
essential component of the gut neuromusculature and controls many aspects of gut function …

Objective. To present any congenital anomalies with respect to tumor necrosis factor (TNF)
antagonists reported to the US Food and Drug Administration (FDA) to determine if there are …

We have identified six children with a distinctive facial phenotype in association with mental
retardation (MR), microcephaly, and short stature, four of whom presented with Hirschsprung …

Tremendous advances have been made over the past two decades in determining the
molecular genetic basis for human inherited diseases. Mutations in an impressive number of …