The role of vitamin D in the endocrinology controlling calcium homeostasis

JC Fleet - Molecular and cellular endocrinology, 2017 - Elsevier
Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole
body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium …

Vitamin D-mediated regulation of intestinal calcium absorption

JC Fleet - Nutrients, 2022 - mdpi.com
Vitamin D is a critical regulator of calcium and bone homeostasis. While vitamin D has
multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) …

Application of in vitro bioaccessibility and bioavailability methods for calcium, carotenoids, folate, iron, magnesium, polyphenols, zinc, and vitamins B6, B12, D, and …

P Etcheverry, MA Grusak, LE Fleige - Frontiers in physiology, 2012 - frontiersin.org
A review of in vitro bioaccessibility and bioavailability methods for polyphenols and selected
nutrients is presented. The review focuses on in vitro solubility, dialyzability, the dynamic …

Calcium absorption across epithelia

JGJ Hoenderop, B Nilius… - Physiological …, 2005 - journals.physiology.org
Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors

JC Fleet, RD Schoch - Critical reviews in clinical laboratory …, 2010 - Taylor & Francis
Optimal intestinal calcium (Ca) absorption is necessary for the protection of bone and the
prevention of osteoporosis. Ca absorption can be represented as the sum of a saturable …

Disorders of calcium and phosphorus metabolism and the proteomics/metabolomics-based research

M Sun, X Wu, Y Yu, L Wang, D Xie, Z Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Since calcium and phosphorus play vital roles in a multitude of physiologic systems,
disorders of calcium and phosphorus metabolism always lead to severe consequences such …

Calcium Transporter 1 and Epithelial Calcium Channel Messenger Ribonucleic Acid Are Differentially Regulated by 1,25 Dihydroxyvitamin D3 in the Intestine and …

Y Song, X Peng, A Porta, H Takanaga, JB Peng… - …, 2003 - academic.oup.com
We examined the expression of calcium transporter 1 (CaT1) and epithelial calcium channel
(ECaC) mRNA in the duodenum and kidney of mice. Intestinal CaT1 mRNA level increased …

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

AK Singh, K Saotome, LL McGoldrick… - Nature …, 2018 - nature.com
Transient receptor potential (TRP) channels are involved in various physiological processes,
including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in …

Vitamin D and the dual processes of intestinal calcium absorption

RH Wasserman - The Journal of nutrition, 2004 - jn.nutrition.org
It is well accepted that the intestinal absorption of calcium occurs by 2 distinct mechanisms,
a saturable active transport process and a nonsaturable passive diffusion process. The …

The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1, 25 …

MB Meyer, M Watanuki, S Kim… - Molecular …, 2006 - academic.oup.com
Transient receptor potential vanilloid type 6 (TRPV6)(ECAC2, CaT1) is the major ion
channel in intestinal epithelial cell membranes responsible for calcium entry. Its expression …