Adolescent idiopathic scoliosis

JC Cheng, RM Castelein, WC Chu… - Nature reviews disease …, 2015 - nature.com
Adolescent idiopathic scoliosis (AIS) is the most common form of structural spinal deformities
that have a radiological lateral Cobb angle—a measure of spinal curvature—of≥ 10. AIS …

International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

J Hamann, G Aust, D Araç, FB Engel… - Pharmacological …, 2015 - Elsevier
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

VEGAS2: software for more flexible gene-based testing

A Mishra, S Macgregor - Twin Research and Human Genetics, 2015 - cambridge.org
Gene-based tests such as versatile gene-based association study (VEGAS) are commonly
used following per-single nucleotide polymorphism (SNP) GWAS (genome-wide association …

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

A Küffer, AKK Lakkaraju, A Mogha, SC Petersen… - Nature, 2016 - nature.com
Ablation of the cellular prion protein PrPC leads to a chronic demyelinating polyneuropathy
affecting Schwann cells. Neuron-restricted expression of PrPC prevents the disease …

Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches

T Schöneberg, I Liebscher, P Insel - Pharmacological reviews, 2021 - Elsevier
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

[HTML][HTML] Suppl-9, M3: Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

M Fadzan, J Bettany-Saltikov - The open orthopaedics journal, 2017 - ncbi.nlm.nih.gov
Adolescent idiopathic scoliosis is one of the most common spinal deformities, yet its cause is
unknown. Various theories look to biomechanical, neuromuscular, genetic, and …

Zebrafish models in translational research: tipping the scales toward advancements in human health

JB Phillips, M Westerfield - Disease models & mechanisms, 2014 - journals.biologists.com
Advances in genomics and next-generation sequencing have provided clinical researchers
with unprecedented opportunities to understand the molecular basis of human genetic …

Adolescent idiopathic scoliosis: a review of aetiological theories of a multifactorial disease

S Marya, AD Tambe, PA Millner… - The bone & joint …, 2022 - boneandjoint.org.uk
Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease

M Hayes, X Gao, LX Yu, N Paria… - Nature …, 2014 - nature.com
Scoliosis is a complex genetic disorder of the musculoskeletal system, characterized by
three-dimensional rotation of the spine. Curvatures caused by malformed vertebrae …