Arginine has multiple metabolic fates and thus is one of the most versatile amino acids. Not
only is it metabolically interconvertible with the amino acids proline and glutamate, but it also …

Leishmaniasis is a vector-borne disease found in many countries worldwide. The causative
agent of the disease, Leishmania spp., lives as an obligate intracellular parasite within …

Hyperinflammation contributes to lung injury and subsequent acute respiratory distress
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …

Macrophages are involved in both innate and adaptative immune responses. Depending on
the types of cytokines that macrophages are exposed to, these cells are subjected to …

Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC),
results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells that expand during benign and cancer-associated inflammation and are characterized …

The metabolism of the amino acid l-arginine is emerging as a crucial mechanism for the
regulation of immune responses. Here, we characterized the impact of l-arginine deprivation …

Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter
of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound …

The amino acid l‐arginine plays a crucial role in the regulation of immune responses. We
have recently shown that uncontrolled replication of Leishmania parasites at the site of …

Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity
because they regulate L-arginine availability. However, their role in the development of …