Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies
During tumor evolution, cancer cells can accumulate numerous genetic alterations, ranging
from single nucleotide mutations to whole-chromosomal changes. Although a great deal of …
from single nucleotide mutations to whole-chromosomal changes. Although a great deal of …
New insights into the mechanism of DNA mismatch repair
GX Reyes, TT Schmidt, RD Kolodner, H Hombauer - Chromosoma, 2015 - Springer
The genome of all organisms is constantly being challenged by endogenous and
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
A Helmrich, M Ballarino, L Tora - Molecular cell, 2011 - cell.com
We show that the time required to transcribe human genes larger than 800 kb spans more
than one complete cell cycle, while their transcription speed equals that of smaller genes …
than one complete cell cycle, while their transcription speed equals that of smaller genes …
Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts
SY Alcoser, DJ Kimmel, SD Borgel, JP Carter… - BMC …, 2011 - Springer
Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo
contain an unknown mix of mouse and human cells. Evaluation of drug activity can be …
contain an unknown mix of mouse and human cells. Evaluation of drug activity can be …
Krimp: mining itemsets that compress
J Vreeken, M Van Leeuwen, A Siebes - Data Mining and Knowledge …, 2011 - Springer
One of the major problems in pattern mining is the explosion of the number of results. Tight
constraints reveal only common knowledge, while loose constraints lead to an explosion in …
constraints reveal only common knowledge, while loose constraints lead to an explosion in …
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target
JBM Koorstra, C Karikari, G Feldmann… - Cancer biology & …, 2009 - Taylor & Francis
Pancreatic cancer is a near uniformly lethal disease and a better understanding of the
molecular basis of this malignancy may lead to improved therapeutics. The Axl receptor …
molecular basis of this malignancy may lead to improved therapeutics. The Axl receptor …
Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis
Y Li, SD Egranov, L Yang, C Lin - Genes, Chromosomes and …, 2019 - Wiley Online Library
Cancer metastasis is a multistep process that requires cancer cells to leave the primary site,
survive in the blood stream, and finally colonize at a distant organ. It is the major cause of …
survive in the blood stream, and finally colonize at a distant organ. It is the major cause of …
Enhanced MAF oncogene expression and breast cancer bone metastasis
Background: There are currently no biomarkers for early breast cancer patient populations at
risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical …
risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical …
Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data
M Baudis - BMC cancer, 2007 - Springer
Background Chromosomal abnormalities have been associated with most human
malignancies, with gains and losses on some genomic regions associated with particular …
malignancies, with gains and losses on some genomic regions associated with particular …
Discovery of microRNA–mRNA modules via population-based probabilistic learning
Abstract Motivation: MicroRNAs (miRNAs) and mRNAs constitute an important part of gene
regulatory networks, influencing diverse biological phenomena. Elucidating closely related …
regulatory networks, influencing diverse biological phenomena. Elucidating closely related …