Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

The glycan chains of vertebrate glycoconjugates are composed mostly of five-and six-
carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto …

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic
enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the …

Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor
for cell entry. These viruses include important human and animal pathogens, such as …

The human polyomavirus, JCV, causes the fatal demyelinating disease progressive
multifocal leukoencephalopathy in immunocompromised patients. We found that the …

Emerging viral diseases are a major threat to global health, and nearly two-thirds of
emerging human infectious diseases are zoonotic. Most of the human epidemics and …

Adeno-associated virus serotype 4 (AAV4) and AAV5 have different tropisms compared to
AAV2 and to each other. We recently reported that α2-3 sialic acid is required for AAV5 …

Sialic acids consist of a family of acidic ninecarbon sugars that are typically located at the
terminal positions of a variety of glycoconjugates. Naturally occurring sialic acids show an …

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain
caused by the JC virus (JCV). PML usually occurs via reactivation of JCV when an immune …