Spatial and temporal control over chemical and biological processes plays a key role in life,
where the whole is often much more than the sum of its parts. Quite trivially, the molecules of …

The development of near-infrared (NIR) fluorescent probes over the past few decades has
changed the way that biomolecules are imaged, and thus represents one of the most rapidly …

The ideal fluorescent probe for bioimaging is bright, absorbs at long wavelengths and can
be implemented flexibly in living cells and in vivo. However, the design of synthetic …

Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Die zeitliche und räumliche Kontrolle über chemische und biologische Prozesse spielt eine
Schlüsselrolle im Leben, wo das Ganze oft viel mehr ist als die Summe seiner Einzelteile …

Optical highlighters are photoactivatable fluorescent molecules that exhibit pronounced
changes in their spectral properties in response to irradiation with light of a specific …

Assessment of protein dynamics in living cells is crucial for understanding their biological
properties and functions. The SNAP‐tag, a self labeling suicide enzyme, presents a tool with …

Fluorescent protein reporters have become the mainstay for tracing cellular circuitry in vivo
but are limited in their versatility. Here we generated Cre-dependent reporter mice …

Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are
engineered cell-surface receptors that sense a target antigen and respond by activating T …

Mammalian cell behavior is strongly influenced by physical and chemical cues originating
from the extracellular matrix (ECM). In vivo, ECM signals are displayed in a spatiotemporally …