The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

▪ Abstract The complement system not only represents an effective innate immune
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …

The complement system as well as the coagulation system has fundamental clinical
implications in the context of life-threatening tissue injury and inflammation. Associations …

Complement-mediated tissue injury in humans occurs upon deposition of immune
complexes, such as in autoimmune diseases and acute respiratory distress syndrome. Acute …

Host immunity to mycobacterial infection is dependent on the activation of T lymphocytes
and their recruitment with monocytes to form granulomas. These discrete foci of activated …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical …

Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in
the presence of antiphospholipid (aPL) Ab's. Currently, therapy for pregnant women with …

The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77),
especially of C5l2, which was originally termed a'default receptor', remains a controversial …

Inflammation, protease/anti‐protease imbalance and oxidative stress play important roles in
the pathogenesis of emphysema. Nrf2 counteracts oxidative tissue damage and …

In the infarcted myocardium, cardiomyocyte necrosis triggers an intense inflammatory
reaction that not only is critical for cardiac repair, but also contributes to adverse remodeling …