Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …

Sodium transport in epithelial tissues is regulated by the physiological mineralocorticoid
aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor …

Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …

Recent evidence has suggested microRNAs as viable therapeutic targets for a wide range of
human disease. However, lack of gene‐specificity of microRNA actions may hinder this …

Two different Ca2+ channels exist in cardiac myocytes. While the L-type Ca2+ channel is
ubiquitous and the main source of Ca2+ for excitation–contraction coupling and pacemaker …

Perception of the role of the aldosterone/mineralocorticoid receptor (MR) ensemble has
been extended from a previously renal epithelial-centered focus on sodium and volume …

Aldosterone's role in the kidney and its pathophysiologic actions in hypertension are well
known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other …

Several large clinical studies have demonstrated the important benefit of mineralocorticoid
receptor (MR) antagonists in patients with heart failure, left ventricular dysfunction after …