The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Lymph node metastasis is a crucial prognostic parameter in many different types of cancers
and a gateway for further dissemination to distant organs. Prior to metastatic dissemination …

Cancer-associated fibroblasts (CAFs) are important components in the tumor
microenvironment, and we sought to identify effective therapeutic targets in CAFs for non …

Although lymph node (LN) metastasis is an important prognostic parameter in cervical
cancer, the tissue remodeling at a pre-metastatic state is poorly documented in LNs. We …

Periostin is a secretory matricellular protein with a multi-domain structure that is composed
of an amino-terminal EMI domain, a tandem repeat of four FAS 1 domains, and a carboxyl …

Identification of additional cancer-associated genes and secondary mutations driving the
metastatic progression in pheochromocytoma and paraganglioma (PPGL) is important for …

In physiological condition, periostin is expressed in limited tissues such as periodontal
ligament, periosteum, and heart valves. Periostin protein is mainly localized on extracellular …

Mass spectrometry imaging (MSI) enables obtaining multidimensional results
simultaneously in a single run, including regiospecificity and m/z values corresponding with …

The self-renewal of spermatogonial cells (SCs) provides the foundation for life-long
spermatogenesis. To date, only a few growth factors have been used for the culture of SCs …

The tumor microenvironment is considered one of the main players in tumor development
and progression. The tumor microenvironment composed of a large number of extracellular …