There is little doubt that the main component of the transmissible agent of spongiform
encephalopathies—the prion—is a conformational variant of the ubiquitous host protein …

There is now very persuasive evidence that the transmissible agent for spongiform
encephalopathies such as scrapie, consists of a modified form of the normal host protein …

The scrapie (PrPsC) and cellular (PrPc) prion proteins are encoded by the same gene, and
their different properties am thought to arise from posttranslational modifications. We have …

Transgenic (Tg) mice expressing both Syrian hamster (Ha) and mouse (Mo) prion protein
(PrP) genes were used to probe the mechanism of scrapie prion replication. Four Tg lines …

The 'protein only'hypothesis postulates that the prion, the agent causing transmissible
spongiform encephalopathies, is PrP (Sc), an isoform of the host protein PrP (C). Protease …

Post-translational modification of the scrapie prion protein (PrP) is thought to account for the
unusual features of this protein. Molecular cloning of a PrP cDNA identified two potential Asn …

PERSISTENT changes in synaptic efficacy are thought to underlie the formation of learning
and memory in the brain1. High-frequency activation of an afferent excitatory fibre system …

The mechanism of protein-only prion replication is controversial. A detailed mathematical
model of prion replication by nucleated polymerisation is developed, and its parameters are …

Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as
Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the …

Proteins were described as distinct biological molecules and their significance in cellular
processes was recognized as early as the 18th century. At the same time, Spanish …