Emerging technologies for cancer therapy using accelerated particles

C Graeff, L Volz, M Durante - Progress in particle and nuclear physics, 2023 - Elsevier
Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

[HTML][HTML] Management of motion and anatomical variations in charged particle therapy: past, present, and into the future

JM Pakela, A Knopf, L Dong, A Rucinski… - Frontiers in …, 2022 - frontiersin.org
The major aim of radiation therapy is to provide curative or palliative treatment to cancerous
malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy …

[HTML][HTML] A survey of practice patterns for real-time intrafractional motion-management in particle therapy

Y Zhang, P Trnkova, T Toshito, B Heijmen… - Physics and imaging in …, 2023 - Elsevier
Background and purpose Organ motion compromises accurate particle therapy delivery.
This study reports on the practice patterns for real-time intrafractional motion-management in …

[HTML][HTML] FLASH radiotherapy using single-energy proton PBS transmission beams for hypofractionation liver cancer: Dose and dose rate quantification

S Wei, H Lin, JI Choi, C Hajj, CB Simone… - Frontiers in …, 2022 - frontiersin.org
Purpose This work aims to study the dose and ultra-high-dose rate characteristics of
transmission proton pencil beam scanning (PBS) FLASH radiotherapy (RT) for …

An integrated physical optimization framework for proton stereotactic body radiation therapy FLASH treatment planning allows dose, dose rate, and linear energy …

R Liu, S Charyyev, N Wahl, W Liu, M Kang… - International Journal of …, 2023 - Elsevier
Purpose Patient-specific ridge filters provide a passive means to modulate proton energy to
obtain a conformal dose. Here we describe a new framework for optimization of filter design …

Use of single‐energy proton pencil beam scanning Bragg peak for intensity‐modulated proton therapy FLASH treatment planning in liver‐hypofractionated radiation …

S Wei, H Lin, C Shi, W Xiong, CC Chen… - Medical …, 2022 - Wiley Online Library
Purpose The transmission proton FLASH technique delivers high doses to the normal tissue
distal to the target, which is less conformal compared to the Bragg peak technique. To …

Validation and clinical implementation of an accurate Monte Carlo code for pencil beam scanning proton therapy

S Huang, M Kang, K Souris, C Ainsley… - Journal of applied …, 2018 - Wiley Online Library
Monte Carlo (MC)‐based dose calculations are generally superior to analytical dose
calculations (ADC) in modeling the dose distribution for proton pencil beam scanning (PBS) …

[HTML][HTML] Towards the clinical implementation of intensity-modulated proton therapy for thoracic indications with moderate motion: Robust optimised plan evaluation by …

CO Ribeiro, S Visser, EW Korevaar… - Radiotherapy and …, 2021 - Elsevier
Purpose Compared to volumetric modulated arc therapy (VMAT), clinical benefits are
anticipated when treating thoracic tumours with intensity-modulated proton therapy (IMPT) …

[HTML][HTML] Advances in the use of motion management and image guidance in radiation therapy treatment for lung cancer

JK Molitoris, T Diwanji, JW Snider III… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
The development of advanced radiation technologies, including intensity-modulated
radiation therapy (IMRT), stereotactic body radiation therapy (SBRT) and proton therapy, has …

[HTML][HTML] Managing treatment-related uncertainties in proton beam radiotherapy for gastrointestinal cancers

EJ Tryggestad, W Liu, MD Pepin… - Journal of …, 2020 - ncbi.nlm.nih.gov
In recent years, there has been rapid adaption of proton beam radiotherapy (RT) for
treatment of various malignancies in the gastrointestinal (GI) tract, with increasing number of …