Increasing evidence points towards mitochondria as crucial players in the initiation and
progression of auto-immune and degenerative disorders, to which impaired cell metabolism …

Transcription factors are crucial to regulate gene expression in immune cells and in other
cell types. In lymphocytes, there are a large number of different transcription factors that are …

Abstract Interleukin-40 (IL-40) is a novel cytokine encoded by the chromosome 17 open
reading frame 99 (C17orf99) gene. Recent studies have shown that IL-40 levels are …

The CTLA4 receptor is an immune checkpoint involved in the downregulation of T cells.
Polymorphisms in this gene have been found to be associated with different diseases like …

Interleukin-17F (IL-17F), considered a pro-inflammatory cytokine, has been shown to
contribute to skeletal tissue degradation and hence chronic inflammation in rheumatoid …

Background PRKCG encodes PKC γ, which is categorized under the classical protein
kinase C family. No studies have specifically established the relationship between PRKCG …

Rheumatoid arthritis (RA), is marked by joint inflammation leading to pannus formation
which results in cartilage destruction promoting bone erosion. The pathological hallmark of …

Abstract Single Nucleotide Polymorphisms (SNPs) are abundantly identified by next
generation sequencing (NGS) technology. Glycogen synthase kinase-3 beta (GSK3B), a …

The inflammasome is a cytosolic multiproteic complex that promotes proinflammatory events
through the release of the cytokines IL-1β and IL-18, and in some context by the induction of …

Background There is still controversy regarding the relationship between hypothyroidism
and rheumatoid arthritis (RA), and there has been a dearth of studies on this association …