Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

The depressive state has been characterised as one of elevated inflammation, which holds
promise for better understanding treatment-resistance in affective disorders as well as for …

Mood disorders have been recognized by the World Health Organization (WHO) as the
leading cause of disability worldwide. Notwithstanding the established efficacy of …

The relationship between high body weight and mental health has been studied for several
decades. Improvements in the quality of epidemiological, mechanistic and psychological …

Depression has been characterized as a disorder of both immune suppression and immune
activation. Markers of impaired cellular immunity (decreased natural killer cell cytotoxicity) …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …

In this study we characterised the ability of the viral mimetic poly I: C to induce a
neuroinflammatory response and induce symptoms of depression and anxiety in rats …

Both depression and sleep disturbance have been linked to inflammation. However, the role
that inflammation plays in the relationship between sleep disturbance and depression …

The kynurenine pathway (KP), which is activated in times of stress and infection has been
implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation …