Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …

Modulators of the arachidonic acid cascade have been in the focus of research for
treatments of inflammation and pain for several decades. Targeting this complex pathway …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-
based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors …

Background Rheumatoid arthritis is characterized by the production of eicosanoids,
cytokines, adhesion molecules, infiltration of T and B lymphocytes in the synovium and …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

Chronic inflammation and pain is a major global health problem, and nonsteroidal anti-
inflammatory drugs (NSAIDs) remain the most frequently prescribed drugs and common …

Most drugs used to treat pain and inflammation act through inhibition of the enzymes
prostaglandin G/H synthase, commonly known as cyclooxygenase (COX). Among these, the …

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional
enzyme exhibiting two different catalytic activities that are located in two distinct domains …

Prostanoids (prostaglandins, prostacyclin and thromboxane) belong to the oxylipin family of
biologically active lipids generated from arachidonic acid (AA). Protanoids control numerous …