Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

During the first 100 years of Alzheimer's disease research, this devastating and intractable
disorder has been characterized at the clinical, histological, and molecular levels …

Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …

Neuronal Fe65 is an adapter protein that interacts with the cytoplasmic domain of the β-
amyloid precursor protein (APP). Although the interaction has been reported to occur …

Proteins encoding phosphotyrosine binding (PTB) domains function as adaptors or scaffolds
to organize the signaling complexes involved in wide-ranging physiological processes …

FE65 binds to the Alzheimer amyloid precursor protein (APP), but the function of this
interaction has not been identified. Here, we report that APP and FE65 are involved in …