[HTML][HTML] Molecular mechanisms of ferroptosis and their involvement in brain diseases
I Costa, DJ Barbosa, S Benfeito, V Silva… - Pharmacology & …, 2023 - Elsevier
Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …
Biomarkers of oxidative stress and antioxidant defense
A number of reactive oxygen and nitrogen species are produced during normal metabolism
in human body. These species can be both radical and non-radical and have varying …
in human body. These species can be both radical and non-radical and have varying …
[HTML][HTML] Ferroptosis in Parkinson's disease: glia–neuron crosstalk
ZL Wang, L Yuan, W Li, JY Li - Trends in molecular medicine, 2022 - cell.com
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …
Ferroptosis and its potential role in the physiopathology of Parkinson's Disease
L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …
characterised by motor impairments as well as non-motor symptoms. While dopamine …
Oxidative stress and cellular pathologies in Parkinson's disease
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
N-Acetylcysteine (NAC): Impacts on Human Health
MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Gut microbiota and metabolome alterations associated with Parkinson's disease
Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several …
intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several …
Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …