AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic
specifically designed to neutralize reactive oxygen and nitrogen species. Research has …

The use of chemical warfare agents is an ongoing, significant threat to both civilians and
military personnel worldwide. Nerve agents are by far the most formidable toxicants in terms …

Reactive oxygen species have an emerging role in the pathologic consequences of status
epilepticus. We have previously demonstrated the efficacy of a water-for-injection …

Porphyrins are large π-aromatic systems that can complex metal ions from all across the
periodic table. The resulting metalloporphyrins are readily tunable with regards to analyte …

This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly
sponsored by the American Thoracic Society (ATS) and the National Institutes of Health …

Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and
mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl …

Nitrogen mustard (NM) is a toxic vesicant that causes acute injury to the respiratory tract.
This is accompanied by an accumulation of activated macrophages in the lung and oxidative …

Abstract Introduction Sulfur Mustard (SM) is one of the most lethal chemicals with major
complications manifested in the lungs. Although the pathogenesis behind SM-induced lung …

Pulmonary injury induced by mustard vesicants and radiation is characterized by DNA
damage, oxidative stress, and inflammation. This is associated with increases in levels of …

Nuclear and chemical weapons of mass destruction share both a tragic and beneficial
legacy in mankind's history and health. The horrific health effects of ionizing radiation and …