Mechanisms of botulinum toxin type A action on pain

I Matak, K Bölcskei, L Bach-Rojecky, Z Helyes - Toxins, 2019 - mdpi.com
Already a well-established treatment for different autonomic and movement disorders, the
use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding …

Botulinum toxin for the treatment of neuropathic pain

JH Park, HJ Park - Toxins, 2017 - mdpi.com
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness,
spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to …

Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomised, double-blind, placebo-controlled trial

N Attal, DC de Andrade, F Adam, D Ranoux… - The Lancet …, 2016 - thelancet.com
Background Data from previous studies suggest that botulinum toxin A has analgesic effects
against peripheral neuropathic pain, but the quality of the evidence is low. We aimed to …

Comparative effectiveness of injection therapies in rotator cuff tendinopathy: a systematic review, pairwise and network meta-analysis of randomized controlled trials

MT Lin, CF Chiang, CH Wu, YT Huang, YK Tu… - Archives of physical …, 2019 - Elsevier
Objective To compare the effectiveness of diverse injections in patients with rotator cuff
tendinopathy using pairwise and network meta-analysis. Data Sources PubMed, EMBASE …

Clinical uses of botulinum neurotoxins: current indications, limitations and future developments

S Chen - Toxins, 2012 - mdpi.com
Botulinum neurotoxins (BoNTs) cause flaccid paralysis by interfering with vesicle fusion and
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …

Subcutaneous injection of botulinum toxin a is beneficial in postherpetic neuralgia

L Xiao, S Mackey, H Hui, D Xong, Q Zhang… - Pain …, 2010 - academic.oup.com
Objective. To assess the benefits of subcutaneous injection of botulinum toxin A (BTX-A) for
the treatment of postherpetic neuralgia (PHN). Design. We investigated the therapeutic …

Botulinum toxin for neuropathic pain: a review of the literature

HM Oh, ME Chung - Toxins, 2015 - mdpi.com
Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used
therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential …

Diffusion, spread, and migration of botulinum toxin

J Ramirez‐Castaneda, J Jankovic… - Movement …, 2013 - Wiley Online Library
Botulinum toxin (BoNT) is an acetylcholine release inhibitor and a neuromuscular blocking
agent used for the treatment of a variety of neurologic and medical conditions. The efficacy …

Behavioral and immunohistochemical evidence for central antinociceptive activity of botulinum toxin A

I Matak, L Bach-Rojecky, B Filipović, Z Lacković - Neuroscience, 2011 - Elsevier
Abstract Botulinum toxin A (BTX-A) is approved for treatment of different cholinergic
hyperactivity disorders, and, recently, migraine headache. Although suggested to act only …

Botulinum toxin A, brain and pain

I Matak, Z Lacković - Progress in neurobiology, 2014 - Elsevier
Botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins known and a potential
biological threat. At the same time, it is among the most widely used therapeutic proteins …