The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin
converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the …

The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

The renin-angiotensin-system (RAS) constitutes an important hormonal system in the
physiological regulation of blood pressure. Indeed, dysregulation of the RAS may lead to the …

Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious
worldwide health concern and a significant healthcare burden. As the majority of …

On March 11, 2020, the World Health Organization declared coronavirus disease 2019
(COVID-19) a pandemic, and the reality of the situation has finally caught up to the …

Angiotensin converting enzyme (ACE) 2 is a homologue of ACE that catalyzes the
conversion of Angiotensin (Ang) II into Ang1-7, which induces vasodilation, anti-fibrotic, anti …

Our current recognition of the renin-angiotensin system is more convoluted than originally
thought due to the discovery of multiple novel enzymes, peptides, and receptors inherent in …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that
degrades angiotensin (Ang) II to Ang-(1–7). ACE2 is highly expressed within the kidneys, it …