Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …

Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic
cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor …

Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells.
The mitochondria form highly organized networks, in which their outer and inner membrane …

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …

The maintenance of cellular function relies on the close regulation of adenosine
triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase …

The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma
(PDA) cells to pharmacologic inhibition of RAS–MAPK signaling are largely unknown. Using …

Neurons are particularly susceptible to energy fluctuations in response to stress.
Mitochondrial fission is highly regulated to generate ATP via oxidative phosphorylation; …

Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an
important regulator of the thermogenic capacity of brown adipocytes. Adipose-specific …

Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer
patients. It manifests especially with energy and mitochondrial metabolism aberrations that …