Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …

The enteric nervous system (ENS) is derived from both the vagal and sacral component of
the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human …

Acquired or congenital disruption in enteric nervous system (ENS) development or function
can lead to significant mechanical dysmotility. ENS restoration through cellular …

The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell
types in an axial position-dependent manner. The production of NC cells from human …

Trait-associated loci often map to genomic regions encoding long noncoding RNAs
(lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show …

The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and
regulates key processes during development and tumorigenesis. The neural crest is an …

The neural crest (NC) is a remarkable transient structure generated during early vertebrate
development. The neural crest progenitors have extensive migratory capacity and …

Schwann cells (SCs) have a critical role in the peripheral nervous system. These cells are
able to support axons during homeostasis and after injury. However, mutations in genes …