Viral infections and their relationship to neurological disorders

J Wouk, DZ Rechenchoski, BCD Rodrigues… - Archives of …, 2021 - Springer
The chronic dysfunction of neuronal cells, both central and peripheral, a characteristic of
neurological disorders, may be caused by irreversible damage and cell death. In 2016, more …

Multifunctional role of astrocytes as gatekeepers of neuronal energy supply

JL Stobart, CM Anderson - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …

Viruses and multiple sclerosis

J Oskari Virtanen, S Jacobson - CNS & Neurological Disorders …, 2012 - ingentaconnect.com
Multiple sclerosis (MS) is a heterogeneous disease that develops as an interplay between
the immune system and environmental stimuli in genetically susceptible individuals. There is …

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

J De Keyser, JP Mostert, MW Koch - Journal of the neurological sciences, 2008 - Elsevier
Once considered little more than the glue that holds neurons in place, astrocytes are now
becoming appreciated for the key roles they play in central nervous system functions. They …

Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

E Harberts, K Yao, JE Wohler, D Maric… - Proceedings of the …, 2011 - National Acad Sciences
Viruses have been implicated in the development of neurodegenerative diseases, such as
Alzheimer's, Parkinson's, and multiple sclerosis. Human herpesvirus-6 (HHV-6) is a …

Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study

LG Epstein, S Shinnar, DC Hesdorffer, DR Nordli… - …, 2012 - Wiley Online Library
Purpose: In a prospective study, Consequences of Prolonged Febrile Seizures in Childhood
(FEBSTAT), we determined the frequency of human herpesvirus (HHV)‐6 and HHV‐7 …

Human herpesviruses 6A and 6B in brain diseases: association versus causation

AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …

Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts

RF Itzhaki - The FASEB Journal, 2017 - Wiley Online Library
Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains
of apolipoprotein E‐«4 carriers, is a major risk for Alzheimer's disease (AD) is increasing …

[HTML][HTML] Tissue specific signature of HHV-6 infection in ME/CFS

F Kasimir, D Toomey, Z Liu, AC Kaiping… - Frontiers in Molecular …, 2022 - frontiersin.org
First exposure to various human herpesviruses (HHVs) including HHV-6, HCMV and EBV
does not cause a life-threatening disease. In fact, most individuals are frequently unaware of …

Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology

JM Hogestyn, DJ Mock… - Neural regeneration …, 2018 - journals.lww.com
Human herpesviruses (HVs) have developed ingenious mechanisms that enable them to
traverse the defenses of the central nervous system (CNS). The ability of HVs to enter a state …