Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening
conditions featuring ineffective immunity characterized by an uncontrolled …

Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Natural killer (NK) cells are part of the innate immune defense against infection and cancer
and are especially useful in combating certain viral pathogens. The utility of NK cells in …

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …

Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the
final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The …

Components of the innate immune response, including neutrophils and macrophages, are
the first line of defense against infections. Their role is to initiate an inflammatory response …

Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an
uncontrolled and ineffective immune response, triggered in most cases by infectious agents …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …