The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

A fundamental goal in biology is to understand the molecular basis of cell identity.
Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors …

Metastatic tumors remain lethal due to primary/acquired resistance to therapy or cancer stem
cell (CSC)-mediated repopulation. We show that a fasting-mimicking diet (FMD) activates …

Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

Fibroblasts, which are the most numerous cell type in the heart, interact with cardiomyocytes
in vitro and affect their function; however, they are considered to play a secondary role in …

It is becoming increasingly clear that the shape of the genome importantly influences
transcription regulation. Pluripotent stem cells such as embryonic stem cells were recently …

Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in
rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and …

Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …