The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Over the past decade, there has been much interest in the regulation of telomerase, the
enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in …

Chronic infections with the hepatitis B virus (HBV) and high-risk human papillomaviruses
(HPVs) are important risk factors for hepatocellular carcinoma (HCC) and cervical cancer …

Ligand 12459, a potent G‐quadruplex‐interacting agent that belongs to the triazine series,
was previously shown to downregulate telomerase activity in the human A549 lung …

Transformation-associated recombination (TAR) cloning represents a unique tool for
isolation and manipulation of large DNA molecules. The technique exploits a high level of …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

Transformation-associated recombination (TAR) protocol allowing the selective isolation of
full-length genes complete with their distal enhancer regions and entire genomic loci with …

Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …

The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by
copying from a short template within its integral RNA component. During telomere synthesis …

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and
regeneration. This requires significant proliferative potential ensured by sufficient telomere …