The recent emergence of organoid technology has attracted great attention in
gastroenterology because the gastrointestinal (GI) tract can be recapitulated in vitro using …

OBJECTIVES: Helicobacter pylori is an identified carcinogen for gastric cancer, however, the
underlying mechanisms remain to be defined. In this review, we sought to elucidate the role …

CagA delivered from Helicobacter pylori into gastric epithelial cells undergoes tyrosine
phosphorylation and induces host cell morphological changes. Here we show that CagA …

Helicobacter pylori infection, which is always associated with gastritis, can progress to
ulceration or malignancy. The diversity in clinical outcomes is partly attributed to the …

Childhood acquisition of Helicobacter pylori is a critical risk factor for gastric cancer. Since
tumorigenesis involves deregulation of proliferation and apoptosis, we examined gastric …

Gastric cancer is one of the leading causes of cancer death worldwide. Because of its
heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis …

Helicobacter pylori infection is associated with chronic gastritis, peptic ulceration, and gastric
carcinoma. The potential role of CD95-mediated apoptosis was investigated in a panel of …

Helicobacter pylori cag+ strains enhance gastric epithelial cell proliferation and attenuate
apoptosis in vivo, which may partially explain the increased risk of gastric cancer associated …

The establishment of persisting Helicobacter pylori infection in laboratory animals has been
difficult, but in 1996 Hirayama reported the development of a successful Mongolian gerbil …

BACKGROUND In the general population, Helicobacter pylori (H. pylori), particularly the
cagA positive strain, has been associated with intestinal‐type gastric carcinoma. Gastric …