Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities.
Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this …

T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Th17 cells play a critical role in both tissue homeostasis and inflammation during clearance
of infections as well as autoimmune and inflammatory disorders. Despite numerous efforts to …

T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of
T cell subsets are integral to their distinct differentiation and functional patterns, the ability of …

Summary Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three
mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant …

Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain.
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …