The integrated genomics of crop domestication and breeding

X Huang, S Huang, B Han, J Li - Cell, 2022 - cell.com
As a major event in human civilization, wild plants were successfully domesticated to be
crops, largely owing to continuing artificial selection. Here, we summarize new discoveries …

Plant pan-genomics and its applications

J Shi, Z Tian, J Lai, X Huang - Molecular Plant, 2023 - cell.com
Plant genomes are so highly diverse that a substantial proportion of genomic sequences are
not shared among individuals. The variable DNA sequences, along with the conserved core …

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

A draft human pangenome reference

WW Liao, M Asri, J Ebler, D Doerr, M Haukness… - Nature, 2023 - nature.com
Abstract Here the Human Pangenome Reference Consortium presents a first draft of the
human pangenome reference. The pangenome contains 47 phased, diploid assemblies …

A graph-based genome and pan-genome variation of the model plant Setaria

Q He, S Tang, H Zhi, J Chen, J Zhang, H Liang… - Nature …, 2023 - nature.com
Setaria italica (foxtail millet), a founder crop of East Asian agriculture, is a model plant for C4
photosynthesis and developing approaches to adaptive breeding across multiple climates …

Building pangenome graphs

E Garrison, A Guarracino, S Heumos, F Villani, Z Bao… - Nature …, 2024 - nature.com
Pangenome graphs can represent all variation between multiple reference genomes, but
current approaches to build them exclude complex sequences or are based upon a single …

Pangenome graph construction from genome alignments with Minigraph-Cactus

G Hickey, J Monlong, J Ebler, AM Novak… - Nature …, 2024 - nature.com
Pangenome references address biases of reference genomes by storing a representative
set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles …

Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet

J Chen, Y Liu, M Liu, W Guo, Y Wang, Q He, W Chen… - Nature Genetics, 2023 - nature.com
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve
cereal production and quality, and ensure food security. Here we present the genetic …

Telomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding

Y Zhang, M Zhao, J Tan, M Huang, X Chu, Y Li… - Nature Genetics, 2024 - nature.com
To decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-
to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus …

Structural variation (SV)-based pan-genome and GWAS reveal the impacts of SVs on the speciation and diversification of allotetraploid cottons

S Jin, Z Han, Y Hu, Z Si, F Dai, L He, Y Cheng, Y Li… - Molecular Plant, 2023 - cell.com
Structural variations (SVs) have long been described as being involved in the origin,
adaption, and domestication of species. However, the underlying genetic and genomic …