Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications

XR Liu, MM Zhang, ML Gross - Chemical reviews, 2020 - ACS Publications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Specificity of glycosaminoglycan–protein interactions

L Kjellén, U Lindahl - Current Opinion in Structural Biology, 2018 - Elsevier
Highlights•Binding of proteins to glycosaminoglycans regulates development and
homeostasis.•Saccharide charge distribution, dynamics and conformation determine protein …

[图书][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

A systems biology approach for the investigation of the heparin/heparan sulfate interactome

A Ori, MC Wilkinson, DG Fernig - Journal of Biological Chemistry, 2011 - ASBMB
A large body of evidence supports the involvement of heparan sulfate (HS) proteoglycans in
physiological processes such as development and diseases including cancer and …

A systems view of the heparan sulfate interactome

A Gómez Toledo, JT Sorrentino… - … of Histochemistry & …, 2021 - journals.sagepub.com
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or
more covalently attached heparan sulfate glycosaminoglycan chains. These chains have …

Heparan sulfate as a regulator of inflammation and immunity

LE Collins, L Troeberg - Journal of leukocyte biology, 2019 - academic.oup.com
Heparan sulfate is found on the surface of most cell types, as well as in basement
membranes and extracellular matrices. Its strong anionic properties and highly variable …

Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use

P Chiodelli, A Bugatti, C Urbinati, M Rusnati - Molecules, 2015 - mdpi.com
Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

[HTML][HTML] Fibroblast growth factors as tissue repair and regeneration therapeutics

QM Nunes, Y Li, C Sun, TK Kinnunen, DG Fernig - PeerJ, 2016 - peerj.com
Cell communication is central to the integration of cell function required for the development
and homeostasis of multicellular animals. Proteins are an important currency of cell …

Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate

L Duchesne, V Octeau, RN Bearon, A Beckett… - PLoS …, 2012 - journals.plos.org
The heparan sulfate (HS) chains of proteoglycans are a key regulatory component of the
extracellular matrices of animal cells, including the pericellular matrix around the plasma …