Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …
functions. Understanding the complexities of protein higher-order structures and dynamics …
Specificity of glycosaminoglycan–protein interactions
Highlights•Binding of proteins to glycosaminoglycans regulates development and
homeostasis.•Saccharide charge distribution, dynamics and conformation determine protein …
homeostasis.•Saccharide charge distribution, dynamics and conformation determine protein …
[图书][B] Chemical reagents for protein modification
RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …
encyclopedic work describing the many approaches to the site-specific modification of …
A systems biology approach for the investigation of the heparin/heparan sulfate interactome
A large body of evidence supports the involvement of heparan sulfate (HS) proteoglycans in
physiological processes such as development and diseases including cancer and …
physiological processes such as development and diseases including cancer and …
A systems view of the heparan sulfate interactome
A Gómez Toledo, JT Sorrentino… - … of Histochemistry & …, 2021 - journals.sagepub.com
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or
more covalently attached heparan sulfate glycosaminoglycan chains. These chains have …
more covalently attached heparan sulfate glycosaminoglycan chains. These chains have …
Heparan sulfate as a regulator of inflammation and immunity
LE Collins, L Troeberg - Journal of leukocyte biology, 2019 - academic.oup.com
Heparan sulfate is found on the surface of most cell types, as well as in basement
membranes and extracellular matrices. Its strong anionic properties and highly variable …
membranes and extracellular matrices. Its strong anionic properties and highly variable …
Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use
Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …
involved in various intertwined pathological processes including virus infection …
[HTML][HTML] Fibroblast growth factors as tissue repair and regeneration therapeutics
Cell communication is central to the integration of cell function required for the development
and homeostasis of multicellular animals. Proteins are an important currency of cell …
and homeostasis of multicellular animals. Proteins are an important currency of cell …
Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate
L Duchesne, V Octeau, RN Bearon, A Beckett… - PLoS …, 2012 - journals.plos.org
The heparan sulfate (HS) chains of proteoglycans are a key regulatory component of the
extracellular matrices of animal cells, including the pericellular matrix around the plasma …
extracellular matrices of animal cells, including the pericellular matrix around the plasma …