[HTML][HTML] mTOR and SGLT-2 Inhibitors: Their Synergistic Effect on Age-Related Processes

D Troise, S Mercuri, B Infante, V Losappio… - International journal of …, 2024 - mdpi.com
The aging process contributes significantly to the onset of chronic diseases, which are the
primary causes of global mortality, morbidity, and healthcare costs. Numerous studies have …

Probiotics and Prebiotics Intervention in Respiratory and Digestive Infections Linked to Covid-19

T Amrouche, S Lammi, D Drider - Probiotics and Antimicrobial Proteins, 2024 - Springer
Probiotics and prebiotics have been suggested as natural agents against viral infections and
dysbiosis and may encourage clinical applications. This review aims to analyze the main …

Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model

C Pinitchun, W Panpetch, T Bhunyakarnjanarat… - PloS one, 2024 - journals.plos.org
Introduction Despite the well-established effects of aging on brain function and gut dysbiosis
(an imbalance in gut microbiota), the influence of aging on sepsis-associated …

Morphine acts via TLR4 resulting in neuroinflammation and immunosuppression

JA Malik, JN Agrewala - Medical Hypotheses, 2024 - Elsevier
Millions of people suffer globally from disorders caused by narcotic substances. Drug
addiction leads to the destruction of an individual's life and risk to public safety. Morphine is …

Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation

ME Caetano‐Silva, A Shrestha, AF Duff, D Kontic… - Aging …, 2024 - Wiley Online Library
Aging is associated with low‐grade inflammation that increases the risk of infection and
disease, yet the underlying mechanisms remain unclear. Gut microbiota composition shifts …

Fiber from elicited butternut pumpkin (Cucurbita moschata D. cv. Ariel) modulates the human intestinal microbiota dysbiosis

JA Nieto, C Rosés, P García-Ibáñez, B Pérez… - International Journal of …, 2024 - Elsevier
Elicited pumpkin was evaluated as a potential daily consumption product able to modulate
the gut microbiota. An in vitro dynamic colonic fermentation performance with microbiota …

The gut microbiome across the lifespan: how diet modulates our microbial ecosystem from infancy to the elderly

H Golshany, SA Helmy, NFS Morsy… - … Journal of Food …, 2024 - Taylor & Francis
This comprehensive review examines the impact of dietary patterns on gut microbiome
composition and diversity from infancy to old age, linking these changes to age-related …

A novel strategy to elicit enduring anti-morphine immunity and relief from addiction by targeting Acr1 protein nano vaccine through TLR-2 to dendritic cells

S Nanda, MA Zafar, T Lamba, JA Malik… - International Journal of …, 2024 - Elsevier
Morphine addiction poses a significant challenge to global healthcare. Current opioid
substitution therapies, such as buprenorphine, naloxone and methadone are effective but …

Comparative analysis of pectin and prebiotics on human microbiota modulation in early life stages and adults

JLS Donadio, JP Fabi - Food & Function, 2024 - pubs.rsc.org
The gut microbiota is essential in human health, influencing various physiological processes
ranging from digestion and metabolism to immune function and mental health. Dietary fiber …

From Defense to Dysfunction: Autophagy's Dual Role in Disease Pathophysiology

JA Malik, MA Zafar, S Singh, S Nanda, H Bashir… - European Journal of …, 2024 - Elsevier
Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining
cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic …