The formalization of biological systems using computational modelling approaches as an
alternative to mathematical-based methods has recently received much interest because …

The eukaryotic cell cycle is robustly designed, with interacting molecules organized within a
definite topology that ensures temporal precision of its phase transitions. Its underlying …

Cell cycle control is fundamental in eukaryotic development. Several modeling efforts have
been used to integrate the complex network of interacting molecular components involved in …

The key roles played by phospholipids in many cellular processes, has led to the
development of model systems, to explore both lipid–lipid and lipid–peptide interactions …

Interaction relationships are fundamental to the behavior of complex systems. This study,
grounded in Boolean discrete systems, conducts a comprehensive investigation of ordered …

Boolean networks introduced by Kauffman, originally intended as a prototypical model for
gaining insights into gene regulatory dynamics, have become a paradigm for understanding …

Many biological processes involve precise cellular state transitions controlled by complex
gene regulation. Here, we use budding yeast cell cycle as a model system and explore how …

Network complexity is required to lend cellular processes flexibility to respond timely to a
variety of dynamic signals, while simultaneously warranting robustness to protect cellular …

In an age where the volume of data regarding biological systems exceeds our ability to
analyse it, many researchers are looking towards systems biology and computational …

Abstract Background In Caenorhabditis elegans early embryo, cell cycles only have two
phases: DNA synthesis and mitosis, which are different from the typical 4-phase cell cycle …