The use of albendazole and mebendazole, ie, benzimidazole broad-spectrum anthelmintics,
in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are …

Filarial nematodes are important helminth parasites of the tropics and a leading cause of
global disability. They include species responsible for onchocerciasis, lymphatic filariasis …

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of
millions of people in the developing world. We have sequenced the∼ 90 megabase (Mb) …

Lymphatic filariasis (LF) is a major cause of acute and chronic morbidity in the tropical and
subtropical parts of the world. The availability of safe, single-dose, drug treatment regimens …

For more than four decades, the free-living nematode Caenorhabditis elegans has been
extensively used in anthelmintic research. Classic genetic screens and heterologous …

Background Albendazole (ABZ), a benzimidazole (BZ) anthelmintic (AH), is commonly used
for treatment of soil-transmitted helminths (STHs). Its regular use increases the possibility …

Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By
binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts …

Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil
in the 1970s. We crossed parental parasites differing~ 500-fold in drug response …

Helminth parasites cause significant morbidity and mortality in endemic countries. Given the
severity of symptoms that helminths may elicit in the host, intervention with prophylactic and …

Most human filarial nematode parasites and arthropods are hosts for a bacterial
endosymbiont, Wolbachia. In filaria, Wolbachia are required for normal development, fertility …