With an increasingly aging society, bone defects and fractures have become significant
threats to human health and quality of life. Currently, autologous and allogeneic bone grafts …

As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

Wnt signaling pathway is one of the most important signaling pathways. The complexity of
Wnt signals and their functional role is crucial in development and growth. It is the most …

The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical
counterpart, the Wnt/b-catenin pathway. The non-canonical Wnt signaling pathways are …

Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential
physiological effects and promising degradation properties. However, excessive release of …

Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture,
which is attributed to its dual function in increasing the bone formation and decreasing the …

Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Immune reactions play important roles in determining the in vivo fate of bone substitute
materials, either in new bone formation or inflammatory fibrous tissue encapsulation. The …

The immune response of peri-titanium (Ti) implants, which is mainly determined by the
surface properties of the Ti implant, may lead to a prolonged healing period and even …

An emerging concept in melanoma biology is that of dynamic, adaptive phenotype
switching, where cells switch from a highly proliferative, poorly invasive phenotype to a …