Microplastics–A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

N Kumar, M Lamba, AK Pachar, S Yadav… - Cell Biochemistry and …, 2024 - Springer
In today's world, the widespread presence of microplastics is undeniable, with
concentrations found in various environments, including up to 1000 particles per liter in …

[HTML][HTML] Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges

J Cong, J Wu, Y Fang, J Wang, X Kong, L Wang… - Environment …, 2024 - Elsevier
Microplastic (MP) pollution has become a global environmental issue, and increasing
concern has been raised about its impact on human health. Current studies on the toxic …

[HTML][HTML] Aerosol exposure at air-liquid-interface (AE-ALI) in vitro toxicity system characterisation: Particle deposition and the importance of air control responses

A Buckley, C Guo, A Laycock, X Cui… - Toxicology in Vitro, 2024 - Elsevier
Experimental systems allowing aerosol exposure (AE) of cell cultures at the air-liquid-
interface (ALI) are increasingly being used to assess the toxicity of inhaled contaminants as …

[HTML][HTML] Assessing toxicity of amorphous nanoplastics in airway-and lung epithelial cells using air-liquid interface models

IF Gosselink, FJ van Schooten, MJ Drittij, EM Höppener… - Chemosphere, 2024 - Elsevier
Background Inhalation is one of the main exposure routes to nanoplastics. Knowledge of the
toxicological impact of nanoplastics on the airway-and lung epithelium is limited and almost …

Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line

C Milillo, E Aruffo, P Di Carlo, A Patruno… - Frontiers in Public …, 2024 - frontiersin.org
Background Nanoplastics, an emerging form of pollution, are easily consumed by organisms
and pose a significant threat to biological functions due to their size, expansive surface area …

Mapping micro (nano) plastics in various organ systems: their emerging links to human diseases?

Y Luo, X Xu, Q Yin, S Liu, M Xing, X Jin, L Shu… - TrAC Trends in …, 2024 - Elsevier
Abstract Micro (nano) plastic (MNP) contamination has become an urgent global
environmental issue, causing immeasurable potential harm to humans. However, direct …

Mutational landscape induced by chronic exposure to environmental PM10 and PM2. 5 in A549 lung epithelial cell

EM Quezada-Maldonado, D Cerrato-Izaguirre… - Chemosphere, 2024 - Elsevier
Exposure to particulate matter (PM) has been linked to an increased risk of multiple
diseases, primarily lung cancer, through various molecular mechanisms. However, the …

[HTML][HTML] Characterization of airborne endotoxin in personal exposure to fine particulate matter (PM2. 5) and bioreactivity for elderly residents in Hong Kong

T Zhang, KH Lui, SSH Ho, J Chen, HC Chuang… - Ecotoxicology and …, 2024 - Elsevier
The heavy metals and bioreactivity properties of endotoxin in personal exposure to fine
particulate matter (PM 2.5) were characterized in the analysis. The average personal …

OCTN1 mediates acetylcholine transport in the A549 lung cancer cells: possible pathophysiological implications

L Pochini, GE Tedesco, T Mazza, M Scalise… - Frontiers in Molecular …, 2024 - frontiersin.org
A role for acetylcholine in cell proliferation, epithelial mesenchymal transition and invasion
has been well assessed and related to the presence of the non-neuronal cholinergic system …

[HTML][HTML] Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan

F Gouveia, A Carona, M Lacerda, J Bicker… - Biochemical …, 2024 - Elsevier
The therapeutic interest of renin-angiotensin system (RAS) drugs for the treatment of
neuroinflammation has been recently acknowledged. Nevertheless, most RAS drugs display …