BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

Organelles move along differentially modified microtubules to establish and maintain their
proper distributions and functions,. However, how cells interpret these post-translational …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into
a perinuclear quality control compartment (ERQC) for the degradation of misfolded proteins …

The dynamic distribution of the microtubule (MT) cytoskeleton is crucial for the shape,
motility, and internal organization of eukaryotic cells. However, the basic principles that …

Adult mammalian central nervous system axons have intrinsically poor regenerative
capacity, so axonal injury has permanent consequences. One approach to enhancing …

By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

The neuronal axon is packed with cytoskeletal filaments, membranes, and organelles, many
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …

Emerging microbe infections, such as Zika virus (ZIKV), pose an increasing threat to human
health. Investigations on ZIKV replication have revealed the construction of replication …