Comprehensive two-dimensional liquid chromatography

L Mondello, P Dugo, P Donato, M Herrero… - Nature Reviews …, 2023 - nature.com
Despite progress in hardware and column technology, the complexity and heterogeneity of
many samples still pose a challenge for state-of-the-art 1D liquid chromatography (LC). As …

Practical considerations in comprehensive two-dimensional liquid chromatography systems (LCxLC) with reversed-phases in both dimensions

D Li, C Jakob, O Schmitz - Analytical and Bioanalytical Chemistry, 2015 - Springer
Online comprehensive two-dimensional liquid chromatography (online LCxLC) presents
high peak capacity compared with one-dimensional liquid chromatography, and reasonable …

Selective comprehensive multi-dimensional separation for resolution enhancement in high performance liquid chromatography. Part I: principles and instrumentation

SR Groskreutz, MM Swenson, LB Secor… - … of Chromatography A, 2012 - Elsevier
An approach to enhancing the resolution of select portions of conventional one-dimensional
high performance liquid chromatography (HPLC) separations was developed, which we …

Optimization of conditions in on-line comprehensive two-dimensional reversed phase liquid chromatography. Experimental comparison with one-dimensional …

M Sarrut, A D'Attoma, S Heinisch - Journal of Chromatography A, 2015 - Elsevier
Comprehensive on-line two-dimensional liquid chromatography is an attractive technique to
enhance peak capacity and deal with complex samples. Yet, its optimization is not …

Multidimensional chromatography coupled to mass spectrometry in analysing complex proteomics samples

P Horvatovich, B Hoekman… - Journal of separation …, 2010 - Wiley Online Library
Multidimensional chromatography coupled to mass spectrometry (LCn‐MS) provides more
separation power and an extended measured dynamic concentration range to analyse …

Theories to support method development in comprehensive two‐dimensional liquid chromatography–A review

F Bedani, PJ Schoenmakers… - Journal of separation …, 2012 - Wiley Online Library
On‐line comprehensive two‐dimensional liquid chromatography techniques promise to
resolve samples that current one‐dimensional liquid chromatography methods cannot …

Micro free flow electrophoresis

AC Johnson, MT Bowser - Lab on a Chip, 2018 - pubs.rsc.org
Micro free-flow electrophoresis (μFFE) is a continuous separation technique in which
analytes are streamed through a perpendicularly applied electric field in a planar separation …

Development of an at-column dilution modulator for flexible and precise control of dilution factors to overcome mobile phase incompatibility in comprehensive two …

Y Chen, J Li, OJ Schmitz - Analytical chemistry, 2019 - ACS Publications
With the combination of different mechanisms, two-dimensional liquid chromatography has
brought revolutionary changes compared to the traditional one-dimensional separation …

Improving peak capacity in fast online comprehensive two-dimensional liquid chromatography with post-first-dimension flow splitting

MR Filgueira, Y Huang, K Witt, C Castells… - Analytical …, 2011 - ACS Publications
The use of flow splitters between the two dimensions in online comprehensive two-
dimensional (2D) liquid chromatography (LC× LC) has not received very much attention, in …

Theoretical evaluation of peak capacity improvements by use of liquid chromatography combined with drift tube ion mobility-mass spectrometry

TJ Causon, S Hann - Journal of Chromatography A, 2015 - Elsevier
In the domain of liquid phase separations, the quality of separation obtainable is most
readily gauged by consideration of classical chromatographic peak capacity theory. Column …