The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …

Despite decades of clinical, sociopolitical, and research efforts, progress in understanding
and treating mental health problems remains disappointing. I discuss two barriers that have …

Why has computational psychiatry yet to influence routine clinical practice? One reason may
be that it has neglected context and temporal dynamics in the models of certain mental …

Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …

Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …

Importance Morning diurnal preference is associated with reduced risk of major depressive
disorder (MDD); however, causality in this association is uncertain. Objective To examine …

Depressive disorders are a leading cause of global disability, afflicting approximately 280
million individuals worldwide each year (1). In the United States, more than one in five …